PO-02-093 IMPACT OF ABLATION OUTCOME ON COGNITIVE FUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION

Emerging evidences suggest increased risk of all forms dementia in patients with atrial fibrillation (AF) even the absence overt stroke. Cerebral hypoperfusion and cerebrovascular micro- macro-embolism are plausible explanations for predisposition cognitive decline AF. We evaluated impact ablation outcome on function AF patients. Consecutive receiving were screened prior to procedure consenting subjects enrolled our COGNITION registry (NCT01816308). Cognitive was assessed using Montreal assessment (MoCA) survey. Patients baseline MoCA score ≤17 excluded from analysis. In this survey, a scale 0-30, 27-30 is considered normal cognition, 18-26 as mild impairment (MCI) ≤ 17 dementia. Post-ablation survey conducted at 1 year. Change 1.7 points clinically significant. Standard institutional protocol followed monitor arrhythmia recurrence quarterly interval during 1-year follow-up period. A total 576 their first catheter registry. At year, 191 (33.1%) experienced (group 1) 385 remained arrhythmia-free off-drugs 2). Baseline characteristics study population given table 1. 20±3.7 group vs 19.2±3.8 2 (p=0.09). follow-up, mean significantly lower (16.05±4.4, p<0.001) higher (21.7±2.4, 2. Mean change -5.08±4.3 2.9±2.6 respectively (p<0.001). series, significant observed following ablation; declined substantially experiencing improved those that arrhythmia-free.